Synthesis, Characterization and Antimicrobial Studies on Bivalent Copper, Nickel and Cobalt Complexes of Thiosemicarbazone

A series of metal complexes of Cu(II), Ni(II) and Co(II) having the general composition [M(L)2]Cl2 [where L= m-nitrobenzaldehyde-4-(4'-sulphoamidephenyl)-3-thiosemicarbazone; M = Cu(II), Ni(II) and Co(II)] have been prepared and characterized by elemental analysis, spectral (IR and H NMR) studies, molar conductance, magnetic susceptibility measurements and thermogravimetric analysis. The spectral data suggests the involvement of thione sulphur and azomethine nitrogen in coordination to the central metal ion. On the basis of above studies, a distorted square-planar geometry and square-planar geometry has been assigned for Cu(II) and Ni(II) complexes respectively, while cobalt(II) complex is tetrahedral in nature. The free ligand and its metal complexes have been tested in vitro against a number of microorganisms. The tested compounds exhibited significant activity.